ISDA: 10EY

Deposition Date 2026-01-15

Release Date 2026-03-25

Last Version Date 2026-04-08

Entry Detail

PDB ID:

10EY

Keywords:

SIGNALING PROTEIN/Imuune System

Title:

SK5B-Matured in complex with GluN1-GluN2B, full refinement

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)

Expression System(s):

Spodoptera frugiperda, Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

4.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glutamate receptor ionotropic
Gene (Uniprot):GRIN1
Chain IDs:A, C
Chain Length:841
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q05586 Pfam ID:PF01094, PF10613, PF00060

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glutamate receptor ionotropic
Gene (Uniprot):GRIN2B
Chain IDs:B, D
Chain Length:826
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q13224 Pfam ID:PF01094, PF10613, PF00060

Polymer Type:polypeptide(L)
Molecule:Light chain
Chain IDs:E, G (auth: I)
Chain Length:111
Number of Molecules:2
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:Heavy chain
Chain IDs:F, H (auth: J)
Chain Length:121
Number of Molecules:2
Biological Source:Mus musculus

Ligand Molecules

Primary Citation

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity.

Kleeman, S.O, Michalski, K, Zhao, X, Steigerwald, R, Ferrer, M, Levett, L, Ertel, E, Schultz, A, Simorowski, N, Moody, P, Wee, T.L, Valente, C, Fox, S, Makuch, M, Thomsen, S, Harrison, R, Regan, C, Preall, J, Gao, Q, Thomas, D, Habel, J, Rubino, R, Irani, S, Furukawa, H, Janowitz, T.Show

Nature ? ? ? (2026)

PMID: 41882353 DOI: 10.1038/s41586-026-10278-0

Primary Citation of related structures

Feedback Form