Study Info
INDA Accessions: INRP000685
INSDC Accessions: PRJEB115524, ERP195726
- Title: Pregnant Women Oral Microbiome Study
- Data Type : Metagenomics
- Descriptive Title: Longitudinal Shifts in Oral Microbiome Composition and Metabolic Pathways Associated with Preterm Birth
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Organism:
Scientific Name(Taxon Id): human oral metagenome (447426) Common Name:
Other Info
- Abstract: Oral dysbiosis in pregnant women with oral diseases has been associated with adverse pregnancy outcomes. However, the inter-individual variability in oral microbiome composition of pregnant women without any oral disease and its role in preterm birth have not been studied yet. Here we have collected saliva from 20 term birth and 20 preterm birth delivering women without any self-reported oral disease at three trimesters. Microbial DNA was subjected to 16S rRNA gene sequencing for taxonomic classification and microbial pathways were investigated by Picrust2. In a subset of samples shotgun metagenomic sequencing was done to identify microbial species, their gene families and pathways. TB and PTB women were distributed into three distinct oral community types OCTs. Haemophilus parainfluenzae and Rothia mucilaginosa were associated with TB and PTB respectively. Chorismate biosynthesis pathway, essential for folic acid biosynthesis, was significantly enriched in TB whereas the enterobactin biosynthesis pathway that produces iron chelators was significantly enriched in PTB. Heterolactic fermentation pathway that reduces oral pH was enriched in PTB. Our data suggest that oral microbiome changes might have an impact on birth outcomes in women even without any history of self-reported oral disease during the pregnancy period.
- Linked publications:
- Center Name: Souvik Mukherjee BRIC-NIBMG, Mousumi Sarkar BRIC-NIBMG, Ankita Maddheshiya BRIC-NIBMG, Shankha Nath BRIC-NIBMG
- Number of Base(Total) Mbp: 32,464,306,000
- Size in bytes(Total): 11,140,112,639
- Number of sample:
- Number of Runs:
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- Number of Assembly:
- Number of Variant files:
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